NR4A Expression by Human Marginal Zone B-Cells

Human tonsil intraepithelial B cells: a marginal zone-related subpopulation.

AIMS To determine if intraepithelial B cells in reactive human palatine tonsils were similar to the marginal zone cells of the spleen and Peyer's patches. METHODS Reactive human palatine tonsils were studied using conventional methods of light microscopy, electron microscopy, and a panel of monoclonal antibodies for leucocyte common antigens. RESULTS Clinically important numbers of marginal...

Capture by Marginal Zone Macrophages Marginal Zone B Cells Regulate Antigen

Circulating splenic marginal zone B cells in human

The human peripheral B cell compartment displays a large population of IgMIgDCD27 “memory” B cell carrying a mutated Ig receptor. We show here, by phenotypic analysis, CDR3 spectratyping during a T-independent response and gene expression profiling of the different blood and splenic B cell subsets, that blood IgMIgDCD27 cells correspond to circulating splenic marginal zone B cells. Furthermore,...

CD1.1 expression by mouse antigen-presenting cells and marginal zone B cells.

Mouse CD1.1 is an MHC class I-like, non-MHC-encoded, surface glycoprotein that can be recognized by T cells, in particular NK1.1+ T cells, a subset of alphabeta T cells with semiinvariant TCRs that promptly releases potent cytokines such as IL-4 and IFN-gamma upon stimulation. To gain insight into the function of CD1.1, a panel of nine mAbs was generated and used to biochemically characterize a...

Human blood IgM " memory " B cells are circulating splenic marginal zone B cells

The human peripheral B cell compartment displays a large population of IgM IgD CD27 memory B cell carrying a mutated Ig + + + “ ” receptor. We show here, by phenotypic analysis, CDR3 spectratyping during a T-independent response and gene expression profiling of the different blood and splenic B cell subsets, that blood IgM IgD CD27 cells correspond to circulating splenic marginal zone B cells. ...